The following article references mental health issues, eating disorders, homophobia, child abuse, and substance misuse.

), as well as poignant storylines.

Behind the laughter, however, the extended cast members have experienced great hardship.

The Big Bang Theory cast posing

Speaking toIris Covet Book, Jim revealed that the loss had a profound effect on him.

The experience reduced Jim to tears.

He later appeared on “Hollywood Medium With Tyler Henry " (viaE!

Jim Parsons posing

), where Henry reassured Jim that his father died quickly, providing him with some closure.

During the show’s run, the actor suffered a devastating loss of his own.

In 2011, Galecki bought a sprawling California ranch with a vineyard.

Johnny Galecki posing

“At first, owning the property was intimidating,” he said.

“I was a city kid and I travel a lot.

But I feel like the place marks a new beginning for me.

Kaley Cuoco posing

I even have a tractor!”

Sadly, this new beginning would be cut short.

Speaking toTMZ, he acknowledged that, as a California resident, he lived in constant fear of wildfires.

Kunal Nayyar posing

“It’s never the structures that create a community it’s the people,” he said.

After rebuilding his home, Galecki was able to put the ranch up for sale two years later.

“Kaley could have lost her leg.”

Simon Helberg posing

“I was like, ‘Did I just fall on a whole thing of leaves?'”

“Because I heard all the cracking …

Subsequently, he confessed that he felt it was right for the show to end after 12 seasons.

Mayim Bialik smiling

“People don’t realize the sacrifice it takes to do an entire season,” he said.

“And for me living away from my family in India …

I’d missed a lot of births and deaths.”

Jim Parsons posing

With therapy and meditation, he was ultimately able to address his anxieties.

“If I’m awful, don’t ever tell me,” he toldThe Guardianin 2016.

“I’m deeply insecure.

Melissa Rauch posing

I ask my wife all the time: ‘Was that OK?

Are people lying?'”

As such, he steers clear of Twitter.

Mayim Bialik posing

Am I good enough?'”

In time, he was able to utilize his insecurities for his performances and reclaim his neuroses.

Away from the cameras,Mayim Bialikhas been open about her mental health issues.

Will Wheaton posing

Well, because I’m a compulsive overeater in addition to being an anorexic and restrictor.”

Despite all his success as an actor, these anxieties never really left him.

However, she gives the initially chauvinistic Howard a run for his money, exhibiting a headstrong personality.

Kate Micucci posing

Melissa Rauch plays Bernadette with aplomb.

Sadly, during “The Big Bang Theory,” the actor suffered a terrible loss.

Accordingly, she lived in fear of losing her baby again.

Kaley Cuoco and John Ritter laughing

“It kick-started a primal depression that lingered in me.

In December 2017, she gave birth to a healthy baby girl, Sadie.

Three years later, she also welcomed a son, Brooks.

Carol Ann Susi looking up

Mayim was devastated by the loss, writing onKvellerthat her dad died after spending two months in hospice care.

“We knew it was coming,” she wrote.

“We had months to process and love and grieve and rage at God and all of that.

Matthew Cowles and Christine Baranski

And then he died …

I appreciate condolences and care and love, but I am alone in the singularity of my loss.”

Over four years later, she returned toKvellerto write another blog post about her dad.

“And then there are the many things I wish I never knew,” she wrote.

“Like what it was like for you to feel your body dying …

I was there to receive them.”

In an interview withYahoo!

Entertainment, Mayim said that she hoped the film would provide some comfort to those suffering from bereavements.

“Death is not difficult, but dying is,” she said.

“There is nothing harder than nursing your parent as they die.”

But his child acting was an unfortunate indicator of long standing trauma.

In a 2021 interview withYahoo!

Wheaton also alleged his father was emotionally abusive.

It’s a little triggering and a little traumatic.”

Around 10% to 20% of lung cancer patients are non-smokers, according to a 2021 study.

“It was a surprise,” the actor said in aTikTokvideo filmed from her hospital bed.

But it’s been a little bit of a trip."

She said that she was taking things slowly, but hopeful of making a full recovery.

Days later, the star posted anotherTikTokvideo with an update on her condition.

“I am very, very lucky and I know that,” she said.

“I’m just really grateful that things worked out as they did.

I’m feeling really good today and I’m honestly just so excited and truly grateful.”

During the filming of Season 2 in September 2003, Ritter became severely ill on set.

He died unexpectedly of a heart condition later that evening, aged 54.

The series continued without Ritter, and saw the fictional Hennessy dealing with Paul’s death.

“I go, ‘Hi!

I heard you’re sick,'” she recalled.

“He goes, ‘I’m okay.

I want to talk to you for a second’ …

I sat down on the couch and he goes, ‘I love you.'”

“I said, ‘I love you too.’

He gave me a hug and that was the last I saw of him.”

People are missing that," she reflected.

Carol Ann Susi died of cancer

In November 2014, Susi was diagnosed with cancer.

Just one week later, she died, aged 62.

Her distraught castmates took to social media to express their sorrow.

“My heart is broken,” Kunal Nayyar wrote on X (via theBBC).

“I will miss your smile.

Your spirit is forever with us.”

Much like the aforementioned “8 Simple Rules,” the show dealt with the loss on screen.

Speaking toThe Hollywood Reporter, showrunner Steve Molaro opened up about the pain of continuing the show without Susi.

It became this mixture of laughter, tears and memories."

While Beverly was devoid of love, Baranski wears her heart on her sleeve.

“It’s been a tough year,” Baranski toldVarietyseveral months after the loss.

Poignantly, she revealed that she welcomed a grandson the same year her husband died.

He was an exceptional person."

The outlet notes that Baranski burst into tears when in the middle of an anecdote about her late husband.

If you or anyone you know needs help with addiction issues, help is available.

Visit theSubstance Abuse and Mental Health Services Administration websiteor contact SAMHSA’s National Helpline at 1-800-662-HELP (4357).

If you need help with an eating disorder, or know someone who does, help is available.