What happens when Meadow Soprano gets together with Jen Harding?

Soprano on the show.

The two women developed a strong bond that began by sharing their experiences with the disease.

Jamie-Lynn Sigler and Christina Applegate holding hands

It turns out, they wound up helping each other.

And I’m angry.

She’s like ‘I have you, and you’re going to be okay.'"

Jamie-Lynn Sigler and Christina Applegate on the red carpet

The actors began their friendship with long phone conversations first about MS, and gradually everything else.

“We haven’t stopped talking since,” Applegate toldPeople.

That’s all it is."

Jamie-Lynn Sigler and Christina Applegate hugging

“It’s the starting point to a conversation about how to push through something that’s hard.”

Beyond their health, the stars have a lot in common.

The beloved TV stars are also incredibly supportive of each other.

Applegate returned the sentiment, telling Sigler, “You are my hero.

You are a poised, beautiful woman.”